The Adrenal Contribution to Androgen Production in Girls During Puberty
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
In girls with elevated androgens the precise source of androgen excess throughout puberty and
early adolescence has not been carefully examined. The investigators propose to examine
whether the adrenal gland produces the majority of androgens during puberty by studying the
differences in androgen responses to adrenocorticotropin hormone (ACTH) administration in
normal weight (NW) and obese (OB) girls ages 7-18. The investigators' analyses will compare
steroid changes before and 60 min after ACTH administration in NW and OB girls.