The Acute Effect of Statins on Inflammatory Markers of Athersclerotic Tissue

• Status: Completed
• Trial end date: 2006-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being done to determine if the acute administration of the drug Simvastatin reduces plaque tissue inflammation and plaque instability in patients undergoing carotid endarectomy

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

• Patients undergoing carotid endarterectomy

• No previously known side effects of statins

• Patients who will sign an informed consent

• Age > 18 years old

• No signs of current infection

Exclusion Criteria:

• Patient hypersensitive to any component of this medication

• Patients with acute liver disease (AST> normal value)

• Patients with chronic liver disease (history of Hepatitis B or C)

• Patients with renal failure (creatinine > 3.0)

• Patients with unexplained muscle pains and aches

• Patients with rheumatoid arthritis

• Patients with Lupus

• Current cancer treatment

• Patients on cyclosporin, digoxin, Itraconazole, Ketoconazole and other antifungal azoles, the macrolide antibiotics and antidepressant nefazodone

• Pregnant females