The Acute Effect of Atorvastain on Renal Function in Patients With Type II Diabetes

• Status: Completed
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium excretion, glomerular filtration rate, tubular function and vasoactive hormones in patients with type II diabetes, not in treatment with insulin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Regional Hospital Holstebro
• Collaborator: Medical Research
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

1. Age: 40-70 yrs

2. estimated GFR between 30 and 90 ml/min

3. BMI<35

4. Fertile women had to use oral contraceptives or IUD

5. HbA1c< 10%

6. Urine-albumin<1,5 g/l

Exclusion Criteria:

1. Treatment with insulin

2. Cerobrovascular insult or other disease of the brain

3. Insufficiency of the heart or lungs

4. Liverdisease with ALAT > 200 U/L

5. hemoglobin < 7,0 mmol/l

6. Cancer

7. Alcohol abuse

8. Medical treatment with psycopharmaca or/and analgetics

9. Pregnancy and breast feeding, 10 blood donation one month before the study.