The Acute Burn ResUscitation Multicenter Prospective Trial

• Status: Recruiting
• Trial end date: 2024-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: American Burn Association
• Collaborator: United States Department of Defense

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• Total burn size (second and third degree) is ≥ 25% of the TBSA

• Burn center admission within 12 hours of injury.

• There is a plan for formal fluid resuscitation.

Exclusion Criteria:

• Significant associated trauma

• High voltage (≥ 1000 volts) electrical burns

• Burn wound excision surgery within 48 hours from injury

• Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury

• Hypertonic saline (HTS) given at any time ≤ 48 hours from injury

• Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury

• High dose Vitamin C infusion given at any time ≤ 48 hours from injury

• Administration of human albumin prior to randomization

• Palliative comfort measures are instituted ≤ 48 hours from injury

• Pregnancy

• Pre-injury chronic renal insufficiency equal to or greater than stage 3

• Pre-injury chronic hepatic disease (Child-Pugh B or C)

• Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)