The 90% Effective Dose of Nalbuphine in Mechanical Ventilated Patients in the ICU

• Status: Unknown status
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine the effective nalbuphine dose in 90% of intubated patients in the ICU, including the continuous infusion dose and a bolus dose during moving to the lateral decubitus position. Pain will assessed using a Behavioural Pain Scale (BPS) requiring a score of 3-4.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hua-Qing Shu
• Treatments: Nalbuphine

Criteria

Inclusion Criteria:

• Mechanical invasive ventilation

• Sedated only with nalbuphine

Exclusion Criteria:

• Pregnant or breast-feeding woman

• Age below 18 or over 80 years

• An indication for deep sedation (e.g.the initial stage of septic shock, acute brain injury or acute respiratory distress syndrome)

• Renal dialysis

• The inability to assess pain by the BPS scale (e.g. paralysis)

• BMI less than 18 or more than 35

• Preadmission use of opioid analgesic for chronic pain

• Severe hepatic failure

• State of consciousness with impossibility to use self-assessment scale; monoamine oxidase inhibitors