Tetracycline (Doxycycline) and Post Myocardial Infarction Remodeling

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to assess the efficacy of an antibiotic treatment with tetracycline (doxycycline) in the early stage of large reperfused acute myocardial infarction (AMI), in preventing left ventricular (LV) remodeling.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Careggi Hospital
• Treatments: Doxycycline; Tetracycline

Criteria

Inclusion Criteria:

• Acute myocardial infarction

• Left ventricular ejection fraction less than 40%

Exclusion Criteria:

• No written consensus

• Allergy to tetracycline

• Mechanical complication of AMI

• Previous myocardial infarction

• Valvular and/or myocardiopathy known or suspected

• Renal failure (creatinine above 2 mg/dL)

• Connective tissue disease

• Pregnancy