Overview

Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations (AVMs) and giant aneurysms.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of California, San Francisco
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)
Treatments:
Doxycycline
Minocycline
Tetracycline
Criteria
Inclusion Criteria:

- Giant aneurysms or brain arteriovenous malformations (BAVM)

- Female patients of child bearing age using effective birth control, males

- Creatinine no greater than 2.0 mg/dl

- ALT no greater than 2 times upper limit of control

Exclusion Criteria:

- Unstable medical illness

- Contraindications to Tetracycline

- History of vestibular disease, (except benign positional vertigo)

- Prior tetracycline use within 2 mos of baseline visit.

- History of noncompliance with treatment or other protocols

- History of systemic lupus

- Patients not eligible for MRI