Purpose of Study:
A) To improve outcome in large population of antipsychotic patients with schizophrenia or
schizoaffective who are only partial responders B) To increase understanding of pharmacology
and mechanisms of action underlying antipsychotic effect
Hypothesis/Objectives of the Study:
Tetrabenazine, through its pre-synaptic action, should augment the post-synaptic effects of
an antipsychotic.
Background and Rationale for the study:
Preliminary evidence that other amine-depleting agents e.g., reserpine, can induce such an
effect