Testosterone Replacement in Postmenopausal Women With Stress Urinary Incontinence
Status:
Completed
Trial end date:
2018-05-31
Target enrollment:
Participant gender:
Summary
The overall objective of this study is to establish if testosterone replacement in
post-menopausal women with low testosterone levels and stress urinary incontinence (SUI) will
lead to improvement in symptoms of SUI.
This study is a prospective, randomized, double-blind, placebo-controlled, parallel-group,
clinical trial and will involve sixty (60) post-menopausal women with clinically diagnosed
stress urinary incontinence and low testosterone concentrations. These subjects will enter
the control period, which involves the baseline measurements of pelvic floor muscle volume
and strength, amounts of urine leakage in 24-hour period, urodynamic parameters, and quality
of life using Incontinence Impact Questionnaire and Urogenital Distress Inventory. Subjects
are then randomly assigned to either placebo (30 subjects) or 300 mcg/twice-weekly
testosterone patch (30 subjects) group. Both the subjects and investigators will be blinded.
The duration of the testosterone/control study will be 36 weeks, with weeks 1-3
screening/control period, 4-28 application of placebo or testosterone patches and 29-36
recovery time/assessment of effects.