Testosterone Replacement in Diabetes With Vascular Disease (Version 2)
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Diabetes is a major cause of peripheral vascular disease(PVD) and is associated with male
hypogonadism. Diabetes and PVD are both associated with arterial stiffness and intima -media
thickness which are also related to severity of the clinical syndrome of PVD. Artificially
induced hypogonadism results in increasing arterial stiffness whilst testosterone is known to
improve risk factors for vascular disease and act as a vasodilator. The purpose of this pilot
study is to assess the effect of testosterone treatment on PVD arterial stiffness and
intima-media thickness in men with type 2 diabetes and hypogonadism,