Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers

• Status: Not yet recruiting
• Trial end date: 2027-12-15

Summary

This phase II/III compares the standard chemotherapy alone to adding bevacizumab to standard chemotherapy, or a combination of just bevacizumab and atezolizumab in treating patients with head and neck cancers that have spread to other places in the body (advanced stage). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab and cetuximab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, carboplatin, and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The addition of bevacizumab and/or atezolizumab could shrink or stabilize head and neck cancers or stop them from growing.

• Phase: Phase 2/Phase 3

Details

• Lead Sponsor: National Cancer Institute (NCI)
• Treatments: Antibodies; Antibodies, Monoclonal; Antineoplastic Agents, Immunological; Atezolizumab; Bevacizumab; Carboplatin; Cetuximab; Cisplatin; Docetaxel; Endothelial Growth Factors; Immunoglobulin G; Immunoglobulins