Overview

Testing the Addition of an Anti-cancer Drug, KRT-232 (AMG 232), to the Usual Treatments (Cytarabine and Idarubicin) in Patients With Acute Myeloid Leukemia

Status:
Suspended

Trial end date:
2022-07-30

Target enrollment:

Participant gender:

Summary

This phase Ib trial studies the side effects and best dose of KRT-232 (AMG 232) when given together with the standard chemotherapy drugs cytarabine and idarubicin in patients with acute myeloid leukemia. KRT-232 (AMG 232) may stop the growth of cancer cells by blocking a protein called MDM2 that is needed for cell growth. Chemotherapy drugs, such as cytarabine and idarubicin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving KRT-232 (AMG 232) with cytarabine and idarubicin may stabilize cancer for longer when compared to giving usual treatments alone.

Phase:

Phase 1

Details

Lead Sponsor:

National Cancer Institute (NCI)

Treatments:

Cytarabine
Idarubicin