Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence
Status:
Terminated
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
This study will test a new medication strategy designed to help smokers quit. It will combine
selegiline, a drug currently approved and available for the treatment of Parkinson's disease,
with a nicotine skin patch. Forty nicotine-dependent smokers will enrolled in this study.
Twenty will receive placebo (inactive pill) plus nicotine patch, and twenty will receive
selegiline plus nicotine patch. Once enrolled in the study, subjects will visit the Nicotine
Dependence Clinic at CAMH on a weekly basis for assessment of smoking behavior, a brief
health check, collection of breath and urine samples (necessary to drug levels and nicotine
levels), and receive brief individual counseling designed to help them stop smoking. The
medication phase of this study lasts 9 weeks. A follow-up visit will be conducted six months
after trial completion. At that point, health and behavioral measures will be re-assessed.