Terbutaline Concentrations in Blood and Urine

• Status: Unknown status
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to assess the blood and urine concentrations of terbutaline and to evaluate the difference between inhaled and oral terbutaline in order to distinguish treatment with terbutaline from doping with terbutaline in a doping control.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bispebjerg Hospital
• Collaborator: Hormone Laboratory, Aker University Hospital, Oslo, Norway
• Treatments: Terbutaline

Criteria

Inclusion Criteria:

• Physician-diagnosed asthma with positive reversibility or challenge test.

• Informed consent.

• Age between 18 - 45 years.

• Sex: male.

• Asthma classified as mild to moderate according to GINA guidelines.

• Used beta-2-agonist in minimum 12 months.

Exclusion Criteria:

• Smokers or ex-smokers with a smoking history of 10 pack years or more.

• Respiratory tract infections within the last 2 weeks prior to visit 1 and 2.

• Subjects with other chronic diseases than asthma and allergy.

• Allergy towards the study medicine.

• Use of beta-2-agonist 6 days prior to study day.