Tenofovir Pharmacology in Older HIV Infected Individuals
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
Tenofovir continues to play a vital role in the treatment of the human immunodeficiency virus
(HIV) and as the age of the HIV-infected population increases in the United States and
worldwide, there is an urgent need to understand the extent to which older age influences the
way this antiretroviral medication works in the body. The investigators study aims to
characterize and compare the pharmacology of tenofovir in older versus younger HIV-infected
adults and to assess kidney function over the course of approximately one year. The
investigators will be analyzing tenofovir levels in different compartments of the blood and
in hair samples, and will be assessing the relationship between tenofovir concentrations and
changes in kidney function over time in the older and younger cohorts. Lastly, the
investigators will be evaluating the relationship between tenofovir concentrations and
functional status (including body composition, bone mineral density, and frailty) in study
participants.