Teniposide Incorporating Bu/Cy Conditioning Regimen for HLH With Central Nervous System Involvemen
Status:
Recruiting
Trial end date:
2025-09-30
Target enrollment:
Participant gender:
Summary
Hemophagocytic lymphohistiocytosis (HLH) is a highly inflammatory disease involving cytokine
storms and is characterised by rapid progression and high mortality. There are no uniform
clinical criteria for the diagnosis of CNS-HLH.And there is still a lack of international
consensus on the treatment for CNS-HLH. Following allogeneic HSCT after HLH induction therapy
is recommended for CNS-HLH. One of the major factors influencing the transplantation effect
is conditioning. Therefore, we conduct a prospective clinical study to explore the efficacy
and safety of Teniposide incorporating Bu/Cy conditioning regimen followed by allogeneic
hematopoietic stem cell transplantation for HLH with central nervous system involvement.