Temsirolimus and Pazopanib in Patients With Advanced Solid Tumors
Status:
Completed
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to test the safety of temsirolimus and pazopanib at different
doses. Patients who have an advanced cancer that is not felt to benefit from standard
treatment or are no longer responding to other treatment will be asked to take part in this
study. The study hypothesis is that temsirolimus and pazopanib can be administered safely in
combination and that combined targeting of the mammalian target of rapamycin (mTOR) and
vascular endothelial growth factor receptor (VEGFR) signaling pathways will be effective in
treating patients with advanced solid tumors.