Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT
Status:
Completed
Trial end date:
2008-11-01
Target enrollment:
Participant gender:
Summary
Total knee arthroplasty (TKA) may be associated with significant blood loss, and transfusion
carries substantial risk of immunologic reaction and disease transmission. Several methods
reportedly reduce postoperative blood loss and avoid homologous blood transfusion with
traditional TKA approaches. Drain clamping was one of the widely used method and tranexamic
acid administration was the recently adjuvant method to reduce blood loss in TKA. However,
there were several regimens in either drain clamping or tranexamic acid administration
reported in previous studies. Our objective was to compare the efficacy of our drain clamping
protocol and/or tranexamic acid regimen for reducing blood loss and transfusion in TKA.