Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Phase I trial to study the safety of combining O6-benzylguanine with temozolomide in treating
children who have recurrent or refractory brain tumors. Drugs used in chemotherapy use
different ways to stop tumor cells from dividing so they stop growing or die.
O6-benzylguanine may increase the effectiveness of temozolomide by making tumor cells more
sensitive to the drug.