Temozolomide and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery
Status:
Completed
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some
block the ability of tumor cells to grow and spread. Others find tumor cells and help kill
them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor
cells by blocking blood flow to the tumor. Giving temozolomide together with bevacizumab may
kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving temozolomide together with
bevacizumab works in treating patients with stage IV melanoma that cannot be removed by
surgery.