The primary aim of this study is to explore the effect of dimethyl fumarate on gray matter
(GM) pathology, as measured by changes in diffusion-tensor imaging (DTI) of the thalamus in
patients with relapsing multiple sclerosis (MS). The secondary objective of this study is to
investigate the effect of dimethyl fumarate on evolution of microstructural changes in normal
appearing white matter (NAWM), as measured by DTI.