Taxotere/Prednisone Plus Sunitinib in Chemotherapy-Naïve, Hormone Refractory Prostate Cancer Patients
Status:
Terminated
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as docetaxel and prednisone, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth and by blocking blood flow to the tumor. Giving docetaxel and
prednisone together with sunitinib malate may kill more tumor cells.
PURPOSE: This pilot phase I/II trial studies the side effects and best way to give docetaxel
and prednisone together with sunitinib malate and to see how well it works in treating
patients with prostate cancer that progressed after hormone therapy.