The investigators plan to enroll up to 60 adult subjects in this study. There will be three
groups of up to 20 subjects each in this study.
Group 1: individuals with OUD and a history of at least one opioid-related OD in the past
year that required naloxone treatment reversal: OUD/OD+ Group 2: individuals with OUD without
a lifetime history of opioid-related OD OUD/OD- Group 3: Healthy controls without a lifetime
OUD: HCs PET/CT imaging will be used to evaluate the uptake of tau in the brain using the
investigational radiotracer [18F]PI-2620. Each subject will have one [18F]PI-2620 positron
emission tomography/computed tomography (PET/CT) scan performed.