Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery (TASD)
Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Chronic Subdural Hematoma (cSDH) is an extremely common problem, particularly in the aging
population, where fluid like collections compress the brain, frequently requiring surgical
drainage. After drainage, 25-50% of patients experience post operative neurologic deficits
such as weakness or confusion that are often not explained by problems such as seizure,
stroke, or mass effect from the fluid and blood. Recent subdural recordings have demonstrated
that some of these neurological deficits may be related to waves of spreading depolarization
(SD), which cause temporary neurological dysfunction. Our overall objective is to examine the
relationship between neurological deficits and SD and to assess feasibility of a pilot trial
to determine if a strategy of NMDA-R antagonism can effectively reduce SD and improve
clinical recovery.