Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation

• Status: Withdrawn
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Stroke and abdominal aortic aneurysms (AAAs) are common and highly lethal vascular diseases. Angiogenesis and infiltration of inflammatory cells such as macrophages may cause stroke and AAAs.

The purpose of this study is to test PET/CT and PET/MRI imaging to specifically detect those diseases using a new developed agent (18F-FPPRGD2) that can target angiogenesis and macrophages.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Treatments: Arginyl-glycyl-aspartic acid

Criteria

Inclusion Criteria:

• Greater than 18 year-old at the time of radiotracer administration

• Provides written informed consent

• Patients diagnosed with either carotid artery stenosis or abdominal aortic aneurysms (AAAs) as identified in Vascular Surgery, in whom a surgical procedure is scheduled

• Able to remain still for duration of an imaging procedure (about one hour).

Exclusion Criteria:

• Less than 18 year-old at the time of radiotracer administration

• Unable to provide written informed consent

• Pregnant women

• Prior carotid or abdominal surgery

• History of radiation therapy to the neck and abdomen

• MRI contraindications (including ferromagnetic objects or devices).