Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery

• Status: Recruiting
• Trial end date: 2025-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI. In a recent randomized controlled trial of patients undergoing major noncardiac surgery, intraoperative individualized blood-pressure management reduced the incidence of postoperative organ dysfunction. The investigators hypothesize that, for patients undergoing off-pump CABG, targeted blood-pressure management during surgery may also reduce the incidence of postoperative AKI.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dong-Xin Wang; Peking University First Hospital
• Treatments: Benzocaine; Norepinephrine; Oxymetazoline; Phenylephrine; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• Age ≥ 50 years;

• Scheduled to undergo off-pump CABG surgery.

Exclusion Criteria:

• Refuse to participate;

• Untreated or uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);

• Chronic kidney disease with a glomerular filtration rate < 30 ml/min/1.73 m2 or end-stage renal disease requiring renal-replacement therapy;

• Inability to communicate during the preoperative period because of coma, profound dementia, language barrier, or end-stage disease;

• Requirement of vasopressors/inotropics to maintain blood pressure before surgery;

• Second or emergency surgery;

• Expected survival of less than 24 hours.