Tapentadol Versus Tramadol Analgesia Post Cardiac Surgery

• Status: Not yet recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this randomized one-blinded study will be to evaluate the efficacy and tolerability of two different oral doses of tapentadol and compare it to tramadol (an opioid commonly used to treat post-surgical pain) in cardiac surgery patients

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aretaieion University Hospital
• Treatments: Tapentadol; Tramadol

Criteria

Inclusion Criteria:

• age <75 years old

• patients discharged from Intensive Care Unit (ICU) in less than 30 hours

• elective cardiac surgery

Exclusion Criteria:

• hepatic failure (increased transaminase levels

• renal failure (creatinine> 2 mg/dL)

• ileus

• emergency surgery (hemorrhage, tamponade, aortic dissection)

• readmission in ICU

• treatment with monoaminoxidase inhibitors, selective serotonine reuptake inhibitors or antiepileptics

• age>75 years old

• communication or language barriers

• Lack of informed consent