Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This phase I/II trial is studying the side effects and best dose of tandutinib and to see how well it works in treating patients with recurrent or progressive glioblastoma.Tandutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute (NCI)

Criteria

Criteria:

• Histologically confirmed glioblastoma:

• Progressive or recurrent disease after prior radiotherapy (with or without chemotherapy)

• Patients with a previous low-grade glioma that progressed after prior radiotherapy (with or without chemotherapy) and are found to have glioblastoma by biopsy are eligible

• Measurable disease, defined as contrast-enhancing progressive or recurrent glioblastoma by MRI or CT imaging within the past 2 weeks

• Must be maintained on a stable corticosteroid regimen from the time of baseline scan to the start of study treatment

• Feasibility study only:

• Planning to undergo surgical resection or biopsy

• Stereotactic biopsy for confirmation of tumor progression or differentiation of tumor progression from treatment-induced effects allowed

• Corticosteroids must be tapered to the lowest required steroid dose and patient must be maintained on a stable dose after surgery or biopsy

• Karnofsky performance status 60-100%

• Absolute neutrophil count >= 1,500/mm^3

• Hemoglobin >= 10 mg/dL

• Bilirubin =< 1.5 mg/dL

• AST and ALT =< 4 times upper limit of normal

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective barrier method contraception during and for 3 months after completion of study treatment

• Mini Mental State Exam score >= 15

• Mean QTc =< 500 msec (with Bazett's correction) by screening electrocardiogram

• LVEF >= 40%

• No history of familial long QT syndrome

• No myocardial infarction within the past 6 months

• No severe uncontrolled ventricular arrhythmias

• No uncontrolled angina

• No electrocardiographic evidence of acute ischemia or active conduction system abnormalities

• No ongoing vomiting or nausea >= grade 2

• No gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for intravenous alimentation

• No active peptic ulcer disease

• No other condition that would impair ability to swallow pills or absorb oral medications

• No muscular dystrophy

• No myasthenia gravis

• No other known or suspected primary muscular or neuromuscular disease

• No history of allergic reactions attributed to compounds of similar chemical or biologic composition to tandutinib (e.g., erlotinib hydrochloride, gefetinib, or doxazosin mesylate)

• Patients who developed an acneiform/maculopustular rash while receiving either gefitinib or erlotinib hydrochloride are eligible unless the rash is considered an allergic reaction (angioedema/urticaria) or Stevens-Johnson syndrome

• No ongoing or active infections

• No psychiatric illness or social situations that would preclude study compliance

• No other serious infection or medical illness

• At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas)

• No other uncontrolled illness

• No other malignancy within the past 5 years except for basal cell or squamous cell skin cancer or carcinoma in situ of the cervix or breast

• Recovered from prior therapy

• At least 3 months since prior radiotherapy

• No prior surgical procedures affecting absorption

• No concurrent combination antiretroviral therapy for HIV-positive patients

• No other concurrent investigational agents

• No concurrent agent that would cause QTc prolongation

• No concurrent prophylactic growth factors (e.g., filgrastim [G-CSF] or sargramostim [GM-CSF])

• At least 10 days since prior and no concurrent anticonvulsant drugs that induce hepatic metabolic enzymes (e.g., primidone, oxcarbazepine, phenytoin, carbamazepine, or phenobarbital)

• No prior treatment with small molecule inhibitors of platelet-derived growth factor receptor (e.g., sunitinib malate, sorafenib, or imatinib mesylate)

• Platelet count >= 100,000/mm^3

• No New York Heart Association class III or IV heart failure

• Creatinine =< 1.5 mg/dL OR creatinine clearance >= 60mL/min