Objective: Evidence indicates that the protein kinase C-PKC signaling cascade may be one of
the direct targets in treatment of mania. The aim of this study is to investigate whether the
PKC inhibitor-tamoxifen has anti-manic properties. Method: Bipolar subjects with manic/mixed
episode were randomly assigned to receive either tamoxifen (80mg/day) or identical placebo
tablets in 1:1 ratio for three weeks.