Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors
Status:
Completed
Trial end date:
2007-10-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as carboplatin and topotecan, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Tamoxifen may help carboplatin work better by making tumor cells more sensitive to
the drug.
PURPOSE: This phase II trial is studying the side effects of giving carboplatin and topotecan
together with tamoxifen and to see how well it works in treating patients with central
nervous system metastases or recurrent brain or spinal cord tumors.