Tailored Hydration for the Prevention of Post-ERCP Pancreatitis

• Status: Not yet recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Aggressive hydration of lactated Ringer's solution has shown considerable beneficial effect in preventing post-ERCP(endoscopic retrograde cholangiopancreatography) pancreatitis. But the occurence rate of post-ERCP pancreatitis are near 10% and there are severe complications of aggressive hydration due to hypervolemia such pulmonary and peripheral edema, prolonged hospital stay and increased medical expense. Also there are no definite guidelines that suggest the duration and amount of hydration.

This study evaluates the efficacy and safety of tailored hydration depending on each patient's condition that indicates the likelihood of developing post-ERCP pancreatitis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chonnam National University Hospital
• Collaborators: Chonbuk National University Hospital; Kwangju christian hospital; Presbyterian medical center; Wonkwang University Hospital
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• All patients older than 20 years undergoing ERCP for the 1st time will be recruited

Exclusion Criteria:

• Age below 20 or above 80 years

• Underlying severe psychiatric illness

• Cardiac insufficiency (>New York Heart Association Class II heart failure)

• Renal insufficiency (eGFR <30mililiter/min/1.73m2)

• Respiratory insufficiency (defined as oxygen saturation < 90%)

• Poorly controlled blood sugar

• Ongoing hypotension including those with sepsis

• Ongoing acute pancreatitis

• Underlying disease of chronic pancreatitis

• Clinical signs of hypervolemia

• Hyponatremia (Na+ levels < 130 milliequivalent (mEq)/L))

• Hypernatremia (Na+ levels > 150mEq/L)

• Hyperkalemia (5.1 mEq/dL)

• Metabolic alkalosis

• Past history of endoscopic sphincterectomy or endoscopic papillary balloon dilatation