Tacrolimus Ointment in Oral Lichen Planus

• Status: Terminated
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effectiveness of topical tacrolimus, triamcinolone and placebo in alleviating signs and symptoms of oral lichen planus (OLP).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oulu
• Collaborator: Kuopio University Hospital
• Treatments: Benzocaine; Tacrolimus; Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• Diagnosis of OLP made by a specialist in oral pathology based on clinical and histopathological features

• Clinical score for OLP ≥ 20 at baseline

• Symptomatic OLP at baseline

• Washout period of 2 weeks

• Age over 18

Exclusion Criteria:

• Pregnant or lactating women

• Allergy to tacrolimus or other macrolides

• Allergy to other drugs or substances used in the study

• Abnormal liver function

• Netherton's syndrome

• Cyclosporin medication

• Other regular medication that could have significant interactions with tacrolimus