Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome
Status:
Completed
Trial end date:
2007-01-01
Target enrollment:
Participant gender:
Summary
Idiopathic membranous nephropathy (IMN) is one of the most common forms of nephrotic syndrome
(NS) in adults and is usually treated by corticosteroids in combination with cytotoxic drugs
especially cyclophosphamide or cyclosporine. Tacrolimus, a new immunosuppressive agent, was
proved to be effective in treating refractory NS. Whether it is effective in IMN has not been
reported. We therefore undertook a multi-center, controlled study to investigate the efficacy
and safety profile of tacrolimus compared with cyclophosphamide in the treatment of patients
with idiopathic membranous nephropathy and nephrotic syndrome.