TRENDY Follow-up: Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular
hemodynamics, and in animal experiments its alteration has been associated with morphological
changes characteristic of diabetic nephropathy. The investigators aimed to assess in a
prospective study: 1. basal NO activity of renal vasculature and 2. renal hemodynamics to
examine whether impairment of basal NO activity of the renal vasculature is related to
development and progression of diabetic nephropathy and other cardiovascular endpoints.