TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma
Status:
Completed
Trial end date:
2015-12-31
Target enrollment:
Participant gender:
Summary
Induction chemotherapy is regarded as an effective way to reduce or downgrade the locally
advanced or aggressive cancers, and to improve the chance of eradication of the locoregional
lesions by radical surgery and/or radiotherapy. However, there are still debates on the
clinical value of induction chemotherapy for patients with advanced and resectable oral
squamous cell carcinoma. The hypothesis of this study is that the induction chemotherapy of
TPF (docetaxel, cisplatin, and 5-fluorouracil) protocol could benefit the patients with
locally advanced oral squamous cell carcinoma. The endpoints of this study are the survival
rate, local control, and safety.