TPA in Acute Stroke With COVID Verus Non-COVID-19 Patients

• Status: Not yet recruiting
• Trial end date: 2022-09-15
• Target enrollment: 0
• Participant gender: All

Summary

The investigator will recruit consecutively all patients coming with acute ischemic stroke either with or without COVID -19 infection and suitable for IV injection with Tissue plasminogen activators according to guideline and inclusion criteria of tPA.

Aswan University Hospital.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Collaborator: Aswan University Hospital
• Treatments: Plasminogen; Tissue Plasminogen Activator

Criteria

Inclusion Criteria:

• Clinically diagnosed as acute ischemic stroke NIHSS<25

• Symptoms onset less than 4.5 hours (3hours in diabetic or having a previous stroke) before beginning treatment.

Exclusion Criteria:

• History of:

• A previous ischemic stroke or severe head trauma in previous 3 months.

• Previous intracranial hemorrhage .

• Intracranial neoplasm or gastrointestinal malignancy.

• Gastrointestinal hemorrhage in previous 3weeks.

• Intracranial or intra spinal surgery in previous 3months

Clinically:

• Symptoms suggestive of subarachnoid hemorrhage.

• Persistent blood pressure elevation, systolic > 185 or diastolic >110 mmHg.

• Active internal bleeding.

• Presentations consistent with infective endocarditis.

• Stroke known or suspected to be associated with aortic arch dissection.

• Acute bleeding diathesis, including but not limited to conditions defined under hematologic.

Hematologic:

• Platelet count <100.000 \ mm3

• Current anticoagulant use with INR>1.7 or PT>15sec or PTT> 40sec.

• Therapeutic doses of low molecular weight received in 24 hours (not include the prophylactic doses).

Head CT:

• Evidence of hemorrhage.

• Extensive regions of obvious hypo density