Overview
TLR-9 Antagonism in Steroid Resistant Optic Neuritis
Status:
Completed
Completed
Trial end date:
2010-05-01
2010-05-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Sudhalkar Eye Hospital
Criteria
Inclusion Criteria:Unilateral Steroid Resistant Optic Neuritis
Exclusion Criteria:
- bilateral optic neuritis
- Associated Systemic disease
- Prior treatment received