TLR-9 Antagonism in Steroid Resistant Optic Neuritis
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
Although idiopathic steroid resistant optic neuritis is very uncommon, there is no
established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9
has been shown to play a role in the pathogenesis of optic neuritis. This small case series
aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9
antagonism)play any role in improving the visual function in such patients.