TEP With 68-DOTANOC in Gastroenteropancreatic Neuroendocrine Tumors

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Evaluation of the diagnostic performance of PET / CT with 68Ga-DOTANOC in Gastroenteropancreatic Neuroendocrine Tumors with comparison with other techniques used in routine clinical practice (octreoscan ® ; multiphase SPECT / CT, MRI or endoscopy).

Therapeutic impact and safety of PET / CT with 68Ga-DOTANOC will also be assessed. Expected results are a confirmation of the superiority of 68Ga-PET DOTANOC versus scintigraphy octreoscan ®, with a potential impact on the therapeutic management of patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nantes University Hospital

Criteria

Inclusion Criteria:

• Age over 18 years

• effective contraception or exclusion of pregnancy dosage of beta-HCG in women of childbearing age

• Fortuitous discovery of suggestive tumors of TE-GEP with well documented conventional imaging (multiphase CT; MRI, US endoscopy) associated or not associated with clinical or biological signs of TE-GEP tumors (increase in tumor markers) OR

• Histologically proven GEP-TE (WHO classification 2010 (26) well differentiated in the initial staging OR

• Suspicion of recurrence or progression of well differentiated TE-GEP tumors on conventional imaging or laboratory tests (increase in tumor markers) OR

• Clinical or biological syndrome strongly suggestive of digestive endocrine disease without identification of lesions with conventional imaging

• Informed consent and patient's written

• Affiliation to an insurance

Exclusion Criteria:

• Multiple endocrine neoplasia

• TE GEP tumor not differentiated

• Pregnancy and lactation

• Persons protected by law

• Restlessness, inability to lie still hold at least 1 hour; Claustrophobia

• Poor compliance predictable or inability to undergo medical test for geographical, social or psychological

• Treatment with radiotherapy, chemotherapy or other antitumor treatment within 6 weeks of previous morphological and scintigraphic examinations. In case of treatment with somatostatin analogues delayed, scans will be performed 4 weeks after the last injection. However, a shorter period may be observed to avoid to do again the initial assessment exams.

• malignancy except basal cell cancers and cancer in situ of the cervix

• Contraindication of injection of a contrast agent necessary for the production of multiphase scanner.

• Patients who had a CT scan without injection of contrast material can not participate in the study