In this multicenter, open label non-randomized phase I/II dose escalation study with
extension cohort HLA-A*0201-positive patients with non small cell lung cancer (NSCLC) can be
included. The primary aim of this study is determine the safety, tolerability and immune
modulating effects of the therapeutic LRPAP1 synthetic long peptide (LRPAP7-30V-SLP) vaccine
(TEIPP24) at different doses. Secondary objectives are to assess the specificity and immune
modulatory effects of the vaccine, to assess the antigen and immune status of the patients,
and to determine progression free survival (PFS), overall survival (OS), and the radiological
tumor response up to one year after first vaccination.