Overview

T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies

Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Objectives: 1. To evaluate disease free survival after Campath 1H-based in vivo T-cell depletion and non-myelo-ablative ablative stem cell transplantation in patients with hematologic malignancies. 2. To evaluate the incidence and severity of acute and chronic GVHD after Campath 1H-based in vivo T-cell depletion, in patients with hematologic malignancies undergoing non-myelo-ablative stem cell transplantation. 3. To evaluate engraftment and chimerism after Campath 1H-based in vivo T-cell depletion and non-myelo-ablative ablative stem cell transplantation in patients with hematologic malignancies.
Phase:
Phase 2
Details
Lead Sponsor:
University of Chicago
Treatments:
Alemtuzumab
Fludarabine
Fludarabine phosphate
Melphalan