Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
Recurrent aphthous stomatitis (RAS) is one of the most common of oral mucosa diseases that
affects approximately 20% of the general population. Despite the fact that clinical,
pathologic and therapeutic feature of the disease has been comprehensively studied, the
pathophysiology of aphthous ulcers remains incompletely understood.
Zinc is a potent catalyst of wound healing and zinc deficiency may be a common cause of
delayed tissue repair. Use of zinc sulfate in promotion wound healing and preservation of
epithelial integrity advocated its possible use in the treatment or prevention of recurrent
oral ulcers.
The purpose of the present study was to determine of systemic zinc sulphate in the treatment
of recurrent aphthous stomatitis.