Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB
Status:
Completed
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
Cardiac surgery has evolved considerably after the advent of cardiopulmonary bypass (CPB), a
feature that allowed more precision and tranquility to the heart surgeon. But their influence
on exacerbation of inflammatory response can unbalance the whole homeostasis so happens
surgical trauma. The attenuation of the systemic inflammatory response in major surgeries
like cardiac surgery for aortic aneurysm appears to represent an important advance in
reducing morbidity and mortality of these patients. Some studies suggest that inhaled
anesthetics such as sevoflurane appear to play an important role in this control, but the
mechanism by which this happens is still unclear. This study has the primary purpose of
analyzing from a clinical study sevoflurane inhalation anesthetic can change the inflammatory
response induced by CPB, significantly reducing the release of inflammatory markers,
especially elastase PMN.