Systemic Hormones and Muscle Protein Synthesis

• Status: Unknown status
• Trial end date: 2019-02-15
• Target enrollment: 0
• Participant gender: Male

Summary

This study evaluates the effect of increase in testosterone levels in older males and the effects of decrease in testosterone levels in young males on muscle protein synthesis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Nottingham
• Treatments: Goserelin; Hormones; Methyltestosterone; Testosterone; Testosterone 17 beta-cypionate; Testosterone enanthate; Testosterone undecanoate

Criteria

Inclusion Criteria:

Young (18-30y) and old (60-75y) males who are generally healthy

Exclusion Criteria:

• Participation in a formal exercise regime

• BMI < 18 or > 30 kg·m2

• Active cardiovascular disease:

• uncontrolled hypertension (BP > 160/100),

• angina,

• heart failure (class III/IV),

• arrhythmia,

• right to left cardiac shunt,

• recent cardiac event

• Taking beta-adrenergic blocking agents, statins, non-steroidal anti-inflammatory drugs or HRT

• Cerebrovascular disease:

• previous stroke,

• aneurysm (large vessel or intracranial)

• epilepsy

• Respiratory disease including:

• pulmonary hypertension,

• COPD,

• asthma,

• Metabolic disease:

• hyper and hypo parathyroidism,

• Hypo and hyper gonadism

• untreated hyper and hypothyroidism,

• Cushing's disease,

• type 1 or 2 diabetes

• Active inflammatory bowel or renal disease

• Malignancy

• Altered hormonal profile

• Recent steroid treatment (within 6 months) or hormone replacement therapy

• Clotting dysfunction

• Musculoskeletal or neurological disorders

• Family history of early (<55y) death from cardiovascular disease