Synthetic vs Natural Estrogen in Combined Oral Contraception
Status:
Completed
Trial end date:
2018-12-30
Target enrollment:
Participant gender:
Summary
The main objective of the study is to compare the metabolic effects of natural estradiol and
synthetic ethinylestradiol used in combined oral contraception in healthy women. A
progestin-only preparation will be used in comparison. The main goal is to study the effects
on glucose metabolism, coagulation and a markers of chronic inflammation (such as hs-CRP).
Our hypothesis is that the natural estradiol preparation will influence blood glucose levels,
markers of coagulation and chronic inflammation less than the ethinylestradiol preparation.
The progestin-only preparation will not effect these parameters.