Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries

• Status: Not yet recruiting
• Trial end date: 2022-08-15
• Target enrollment: 0
• Participant gender: All

Summary

Acute limb injury is a common reason to visit an emergency department worldwide. Intense pain related to the injury is always a concern for an emergency physician and requires effective analgesia within the shortest possible time. Non-steroidal anti-inflammatory drugs (NSAIDs), opioids and paracetamol are the commonly used drugs in an emergency department. The choice of analgesia should be established by its efficacy, logistics involved and route of administration. There is good evidence about NSAIDs being the first line analgesia and paracetamol is reported to have the narcotic sparing effect, either alone or as an adjunctive treatment in different settings. The synergistic effect of paracetamol with diclofenac in acute limb injuries related pain management lacks good- quality evidence. Therefore investigators proposed a large, well designed, randomized double-blind trial to develop high-quality evidence. The study aims to assess the efficacy of paracetamol in addition to diclofenac, and compare the difference between oral and intravenous paracetamol administration in acute limb injuries in the emergency department.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hamad Medical Corporation
• Treatments: Acetaminophen; Diclofenac

Criteria

Inclusion Criteria:

• Age 18 years upto 65 years

• Vitals Stable

• musculoskeletal limb injury

• initial pain score of 5 or more on a NRS (numerical rating scale)

Exclusion Criteria:

• Patient received any pain medication prior to 8 hours

• Allergies to either diclofenac or paracetamol

• Contraindication to the study drugs

• CVA

• Bronchial asthma

• GI bleeding

• Renal impairment

• Asthma

• Pregnancy and nursing

• Unstable traumatic patient