Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses
Status:
Completed
Trial end date:
2019-04-01
Target enrollment:
Participant gender:
Summary
Background: The mechanisms of action of intravenous anesthetics are unclear and the current
monitors have limitations.
This signifies difficulties when assessing the correct dosage due to the considerable
inter-individual variability of the patients, particularly in the elderly or seriously ill.
It is necessary to customize the administration of anesthetics as underdosage can lead to the
patient awareness during aggressive procedures, and over-dosage can cause serious
complications and even augment mortality.
Objective: To design a new monitoring system of the levels of consciousness and analgesia in
anesthetized subjects which is more accurate than those currently employed. It will be based
on the synchronic changes of functional magnetic resonance (fMR) and electroencephalograph
(EEG) readings, and clinical responses.
Methodology: Thirty healthy volunteers will be given propofol and remifentanil in different
combinations, and painful stimuli will be also applied. The principal variable will be fMR
images obtained by echo-planar imaging sequences. Real time will be correlated with cortical
connectivity maps (connectome), EEG parameters (qCON, qNOX), clinical responses, and
concentrations of anesthetics measured by pharmacokinetic and pharmacodynamic models (TCI).