Overview

Synchronization of Follicle Wave Emergence and Ovarian Stimulation

Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
0
Participant gender:
Female
Summary
The objective of the study is to elucidate the effect of synchronizing initiation of ovarian stimulation treatment with follicular wave emergence in poor responder patients undergoing IVF/ICSI and ET. We hypothesize that initiating treatment on day 1 versus day 4 of the cycle will increase the number of follicles recruited and oocytes retrieved.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Saskatchewan
Collaborator:
Royal University Hospital Foundation
Treatments:
Cetrorelix
Criteria
Inclusion Criteria:

- Informed consent obtained

- Age of 43 years or younger

- 18 < BMI < 35

- History of poor response to ovarian stimulation as determined by:

- previously cancelled oocyte retrieval procedure due to < 4 follicles greater than
12 mm on ultrasound OR

- < 3 mature oocytes

- Physical exam performed within the past 12 months

- Normal or corrected levels of TSH and Prolactin within the past 12 months

- Has not taken ovarian suppression therapy within 1 month of initiating study drug

Exclusion Criteria:

- Chronic medical conditions such as renal failure

- Documented ovarian failure

- Presence of only one ovary

- Serum Day 3 FSH > 12 IU/L within the past 6 months

- Ovaries inaccessible transvaginally

- Concomitant glucocorticoid use

- Ongoing pregnancy

- Any contraindications to ovarian stimulation treatment

- Participation in an investigational drug trial in the 30 days prior to the pre-study
visit