Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting.
Status:
Terminated
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
We propose to perform a randomized controlled patient and assessor blind trial in women
between the ages of 18 to 70 years with acute uncomplicated UTI to evaluate initial
symptomatic treatment for 3 days with the non-steroidal anti-inflammatory drug diclofenac
(experimental intervention) against immediate antibiotic treatment with norfloxacin for 3
days (control intervention). Both interventions are followed by optional delayed antibiotic
treatment with single dose fosfomycin if deemed necessary by the patients. The primary
objective is to determine whether initial symptomatic treatment followed by optional delayed
antibiotic treatment (experimental intervention) is non-inferior to immediate antibiotic
treatment (control intervention) in terms of symptom resolution.
Phase:
Phase 4
Details
Lead Sponsor:
University Hospital Inselspital, Berne
Collaborators:
Clinic for Infectious Diseases, University Hospital Bern, Switzerland University of Bern