The goal of this clinical trial is to test a treatment strategy for individuals with opioid
use disorder (OUD) who use fentanyl. Participants will receive medically-administered doses
of intravenous (IV) fentanyl at intervals until they are comfortable and do not have
withdrawal symptoms. They then will be given opioid agonist therapy (OAT) once daily by
mouth, which is the current standard treatment for OUD. In this trial, each participant's
starting dose of OAT will be tailored to meet their opioid needs, based on the amount of IV
fentanyl they received.
The main questions this trial aims to answer are:
- Is the IV fentanyl protocol feasible and safe for use in a community clinic setting?
- Will the protocol result in higher-than-standard starting doses of OAT? Are these doses
safe, and will they enable participants to stay on OAT for a longer time?