Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
The main purpose of research is to examine and understanding the development of hypertension
in obese adults with insulin resistance. Findings from our studies will identify unique
mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the
excessively high prevalence of hypertension and risk for cardiovascular disease (CVD).
This study is testing the health of the blood vessels and the activity of the nerves that
control the blood vessels in adults with insulin resistance. The extent to which ascorbic
acid (Vitamin C) improves the function of the blood vessels will be determined. The primary
outcome is blood pressure, which is the result of blood vessel health and activity of the
nerves, and the reduction in blood pressure that is observed with ascorbic acid.